腹腔镜脾切除治疗门静脉高压症及术后并发症的危险因素分析

Analysis of postoperative complications and risk factors in patients with portal hypertension treated by laparoscopic splenectomy

  • 摘要: 目的
    评价腹腔镜脾切除术治疗门静脉高压症术后并发症的发生情况,并分析影响术后并发症发生的危险因素。
    方法
    回顾性分析2003年9月至2012年9月四川大学华西医院收治的65例行腹腔镜脾切除术的肝硬化门静脉高压症患者的临床资料。采用改良的Clavien分级系统分析术后并发症,并分析影响患者术后并发症发生的危险因素。计量资料采 用t检验,计数资料采用χ 2检验 和Fisher确切概率法,单因素及多因素分析采用Logistic回归模型分析。
    结果
    本组患者中,36例行全腹腔镜脾切除术 (2例因 术中出血中转开腹手术),29例行手助式腹腔镜脾切除术。术后16例患者发生20例次并发症,行全腹腔镜脾切除术患者术后并发症发生率为 38.2%(13/34),高于行手助式腹腔镜脾切除术患者的10.3% (3/29),两者比较,差异有统计学意义( χ 2 =21.60,5.10,P <0.05)。多因素分析结果显示:ASA Ⅲ级和未使用手助器是术后并发症发生的独立危险因素( OR=23.60,4.60,P <0.05)。ASA Ⅲ级患者术后并发症发生率是Ⅱ级患者的17.00倍,未使用手助器患者术后并发症发生率是使用手助器患者的5.00倍。
    结论腹腔镜 脾切除术治疗肝硬化门静脉高压症术后并发症的发生率高,但主要集中在ASA Ⅲ级以下患者,ASA分级和手助器的使用与术后并发症的发生有关。

     

    Abstract: Objective
    To investigate the postoperative complications after laparoscopic splenectomy for patients with portal hypertension, and analyze the risk factors for postoperative complications.
    Methods
    The clinical data of 65 patients with portal hypertension who received laparoscopic splenectomy at the West China Hospital from September 2003 to September 2012 were retrospectively analyzed. The postoperative complications were analyzed using the modified Clavien classification system, and the risk factors for postoperative complications were analyzed. The measurement data and the count data were analyzed using the t test, chi square test or the Fisher exact probability. The univariate and multivariate analysis were done using the Logistic regression model.
    Results
    Twenty nine patients received hand assisted laparoscopic splenectomy and 36 received total laparoscopic splenectomy (2 patients were converted to open surgery due to intraoperative bleeding). Sixteen patients had 20 complications. The incidence of postoperative complications of the hand assisted laparoscopic group was 10.3%(3/29), which was significantly lower than 38.2%(13/34) of the total laparoscopic group ( χ 2 =21.60, 5.10, P <0.05). The results of multivariate analysis showed that ASA grade Ⅲ and non application of hand assisted device were independent risk factors for postoperative complications ( OR=23.60, 4.60, P < 0.05) . The incidence of postoperative complications of patients with ASA grade Ⅲ were 17.00 times higher than patients with ASA grade Ⅱ, and the incidence of postoperative complications of patients who received total laparoscopic splenectomy was 5.00 times higher than those who received hand assisted laparoscopic splenectomy.
    Conclusions
    The incidence of postoperative complications is higher in patients with portal hypertension, while the severity of the complications is under ASA grade Ⅲ. ASA classification and application of hand assisted device are correlated with the incidence of postoperative complications.

     

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